Team Grant: E-Rare-6 Joint Transnational Call

The topic of the call is Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases.

Projects shall focus on a group of rare diseases or a single rare disease following the European definition i.e. a disease affecting not more than five in 10.000 persons in the European Community, EC associated states, Australia and Canada. Applicants are encouraged to assemble groups of rare diseases based on relevant criteria and commonalities if this leverages added value in sharing resources or expertise.

Research Areas

This funding opportunity will support transnational research proposals relevant to at least one of the following areas:

  1. Phenotype-driven diagnosis: integration across different ontologies, integration of shared pathways, digital phenotyping, development of artificial intelligence approaches/applications to extract health related data in aid of diagnosis;
  2. Prognostic markers/biomarkers investigations for early diagnosis and monitoring;
  3. Methodologies for solving cases that are currently difficult to analyze due to different underlying mechanisms (e.g. mosaicism, genomic (non-coding) alterations, gene regulation, complex inheritance), including new genomics / functional genomics technologies, multi-omics, mathematics, biostatistics, bioinformatics and artificial intelligence approaches; 
  4. Functional strategies to globally stratify variants of unknown significance (VUS) for clinical use; setting up of (in vitro) systems to distinguish between VUS and pathogenic variants (e.g. confirming disruption of splicing for deep intronic variants, loss of protein function, and gain of toxic protein function); 
  5. Development of pathway models to enable diagnosis, especially for newly discovered diseases that may share underlying molecular mechanisms with already known diseases.

Funds Available

  • The total amount available for this funding opportunity is CAD 2,250,000, enough to fund approximately 5 grants from all Canadian funding sources. This amount may increase if additional funding partners participate. The maximum amount per grant is CAD150,000 per year for up to 3 years, for a total of CAD 450,000 per grant.

Eligibility to Apply

  1. The Nominated Principal Applicant (NPA) leading the Canadian component must be an independent researcher affiliated with a Canadian postsecondary institution and/or its affiliated institutions.
  2. The NPA must have their substantive role in Canada for the duration of the requested grant term.
  3. The Institution Paid for the Canadian application must be authorized to administer CIHR funds by the application deadline.
  4. If the Canadian team in the consortium includes more than one Canadian researcher, only one of them must be named the NPA on the abbreviated application submitted to CIHR.
  5. CIHR’s Early Career Researcher definition will be followed for the Canadian applicants.

For FRQS eligibility information, please consult their General Common Rules.

All Canadian applications must additionally meet EJP RD JTC2022 eligibility.

How to Apply

  • The application process for this funding opportunity is comprised of two steps for Canadian applicants, with additional sub-steps for Quebec applicants only: 

Step 1a – Pre-Proposal to EJP RD:

  • Pre-Proposals must be submitted in English only to EJP RD. For more information, consult EJP RD JTC2022.
  • Note that no documents need to be submitted to CIHR at the pre-proposal stage.

Step 1b – Pre-Application to FRQS (for Quebec applicants only):

  • In addition to the Pre-Proposal to EJP RD, Quebec applicants are also required to complete an application form to be considered for FRQS funding and must consult the FRQS website.
  • The deadline for submission of this pre-application is the same as the Pre-Proposal deadline to the EJP RD JTC2022.

Step 2a – Full Proposal to EJP RD:

  • Invitations to submit Full Proposal are expected to be sent in April 2022 by the Joint Call Secretariat.
  • Full Proposals must be submitted in English only to EJP RD. For more information, consult EJP RD JTC2022.

Step 2b – Abbreviated Application to CIHR:

The purpose of this additional application to CIHR is to provide CIHR with an operating budget for the project, with the amounts quoted in Canadian dollars, a complete justification for funds requested, and a one-page research summary of the project.

Step 2c - Application to FRQS (for Quebec applicants only).

Deadlines:

Pre-Proposal to EJP RD: Feb 16, 2022

Full Proposal to EJP RD and Abbreviated Application to CIHR (202206ERT): June 15, 2022

WEBSITE

SFU Signature Sheet, CIHR Routing Slip and Full Applications are due to ORS 3 business days before the application deadline. 

 

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